|Kehrli jr, Marcus|
Submitted to: Mastitis Council Meeting Proceedings
Publication Type: Proceedings
Publication Acceptance Date: 12/15/2005
Publication Date: 1/22/2006
Citation: Burvenich, C., Kehrli, Jr., M.E., Paape, M.J. 2006. Individual cow responses to Escherichia coli mastitis. In: Proceedings of the 45th National Mastitis Council, January 22-25, 2006, Tampa, Florida. 45:61-87. Interpretive Summary:
Technical Abstract: A high proportion of intramammary coliform infections present at parturition, may develop disease characterized by severe inflammatory signs and sepsis during the first 60-70 days of lactation. In the lactating bovine mammary gland innate immunity is the most important defense system. Since the beginning of the 90ies, research on bovine mammary innate defense mechanisms in connection with the pathogenesis of coliform mastitis, increased significantly. There is no doubt that several innate immune proteins provide a measure of protection in the mammary gland cisterns. However, in the bovine udder the protective role of some of them seem to be unimportant and some of them have actions that depend on the stage of the lactation cycle. During the last 30 years most efforts have been focused on diapedesis, phagocytosis and killing by neutrophils, one of the most important components of the efferent innate arm. How these functions modulate the clinical outcome of coliform mastitis and how they can be influenced have also been the subject of intensive research. The study of the afferent (sensing) arm that recognizes a diverse array of pathogens is a new area of interest.