Submitted to: Journal of Federation of American Societies for Experimental Biology
Publication Type: Abstract Only
Publication Acceptance Date: 12/15/2005
Publication Date: 3/1/2006
Citation: Diaz, M., Watkins, B., Li, Y., Campbell, W., Anderson, R.A. 2006. Chromium picolinate and conjugated linoleic acid: effects on diet and exercise-induced changes in metabolic and cardiovascular health indexes in overweight women (abstract). Journal of Federation of American Societies for Experimental Biology. 20:A592. Interpretive Summary:
Technical Abstract: This study assessed the combined effects of chromium picolinate (CP) and conjugated linoleic acid (CLA) on energy-restriction and exercise-induced changes in body composition, glucose metabolism, lipid-lipoprotein profile, and blood pressure in overweight and obese, pre-menopausal women. For 12 wk, 35 women (age 36±1 y (mean±SEM); BMI 28.0±0.5 kg/m2) consumed a 500 kcal/d energy deficit diet and performed 30 min of moderate exercise 5x/wk. The women also ingested either CP-CLA (S, 400 µg Cr, 2.4 g CLA, n=19) or placebo (P, <0.1 µg Cr, 2.4 g canola oil, n=16). Urinary Cr excretion increased 22-fold, plasma fatty acid 18:2 (c9,t11) content increased 79%, and 18:2 (t10,c12) became detectable in S, and were unchanged in P. Over time, VO2max increased (S 1.9'±.3; P 3.9± 1.5 mL•kg-1•min-1), and body weight (S -2.6±0.5; P -2.5±0.5 kg) and % body fat (S -2.4±0.4, P -2.2±0.5 %) decreased, with no differences between groups. All other indexes of glucose metabolism (fasting plasma glucose, insulin and hemoglobin A1c), lipid-lipoprotein profile (serum total cholesterol, HDL, LDL, and triacylglycerol), and blood pressure (sitting systolic and diastolic) were not changed over time or influenced by S. These results suggest that chromium picolinate and conjugated linoleic acid supplementation does not affect diet and exercise-induced changes in weight, body composition, and indexes of metabolic and cardiovascular health in young, overweight women.