Submitted to: Agricultural Experiment Station Publication
Publication Type: Experiment Station
Publication Acceptance Date: 12/1/2005
Publication Date: 12/14/2005
Citation: Lunney, J.K. 2005. Porcine reproductive and respiratory syndrome (prrs): methods for the integrated control, prevention, and elimination of prrs in united states swine herds. Agricultural Experiment Station Publication. Available: http://www.prrs.org/NC229.htm
Technical Abstract: The NC-229 national project “Porcine Reproductive and Respiratory Syndrome (PRRS): Methods for the integrated control, prevention, and elimination of PRRS in United States swine herds” This station report summarizes the BARC lab’s recent research progress on the first objective, virus replication in the individual host (e.g., host genetics, immunity, persistence, pathogenesis, viral genome, anti-virals, vaccinology). Results of genetic studies with Univ. Nebraska scientists have revealed that levels of some immune genes may determine whether pigs will effectively limit virus replication after infection with PRRSV. These studies have highlighted targets for future studies of genetic association for PRRS resistance, specifically levels of innate cytokine interleukin-8 in serum and tissue expression of interferon-gamma. Such information will enable producers to decrease breeding of PRRSV susceptible pigs, and select for PRRSV resistant stock.