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ARS Home » Plains Area » Lubbock, Texas » Cropping Systems Research Laboratory » Livestock Issues Research » Research » Publications at this Location » Publication #188077
Title: LONG TERM DIETARY SUPPLEMENTATION OF ORGANIC SELENIUM ENHANCES EXPRESSION OF IMMUNE RELATED GENES IN ADULT PIGS

Author
item Dowd, Scot
item KIM, SUNGWOO - TEXAS TECH UNIVERSITY
item MATEO, RONALD - TEXAS TECH UNIVERSITY
item YOON, IAN - TEXAS TECH UNIVERSITY

Submitted to: Federation of American Societies for Experimental Biology Conference
Publication Type: Abstract Only
Publication Acceptance Date: 1/15/2006
Publication Date: 4/1/2006
Citation: Dowd, S.E., Kim, S., Mateo, R., Yoon, I. 2006. Long term dietary supplementation of organic selenium enhances expression of immune related genes in adult pigs [abstract]. Federation of American Societies for Experimental Biology Conference Abstracts. Available: http://www.eb2006-online.com/pdfs/006709.PDF?PHPSESSID=f07543fef8761587d860af5e0239a3bf.

Interpretive Summary:

Technical Abstract: Ninety-six pigs at 34.4 kg body weight were allotted to two dietary treatment groups with six replicates per treatment and eight pigs per pen, the control (no added selenium) and the OS (0.36 mg/kg added selenium from selenium enriched yeast). Pigs were fed for 110 days until 130.0 kg body weight based on three phase feeding programs with nutrient levels recommended by National Research Council only except for selenium. The control diet contained 0.18 mg/kg indigenous Se, whereas the OS diet contained 0.54 mg/kg Se. Blood samples were collected at 1000 h and further processed for the microarray analysis. Microarray chips were prepared with 800 genes related to immune function of pigs. Among those, 27 genes related to improved immune status and innate immunity were up-regulated (P < 0.05) and those include growth arrest homeobox transcription factor (43.9%), toll-like receptor 2 precursor (12.2%), vanin-1 (65.5%), lysozyme C-3 precursor (10.8%), amyloid beta A4 protein precursor (91.1%), integrin beta-1 subunit (20.0%), myelin, and lymphocyte protein (51.2%), etc. This study indicates that long-term dietary supplementation (0.3%) of Se as an organic form improves the expression of genes that are related to enhanced immunity of pigs.