Submitted to: Meeting Abstract
Publication Type: Other
Publication Acceptance Date: 11/11/2005
Publication Date: 11/11/2005
Citation: Oppert, B.S., Lorenzen, M.D., Beeman, R.W., Adang, M.J. 2005. Annotation of cadherin genes in the tribolium genome [Abstract]. First Annual Symposium on Computational and Systems Biology, Athens, GA, November 11, 2005. Interpretive Summary:
Technical Abstract: Cadherins represent a highly conserved family of proteins that mediate calcium-dependent cell-cell adhesion. Cadherins also function as receptors for the insecticidal proteins from Bacillus thuringiensis (Bt), and some examples of insect resistance to Bt have been attributed to disruptions in cadherin genes. As an ongoing project to identify cadherins in coleopteran pests and to investigate their potential role in mediating Bt toxicity, we have identified several cadherin genes from the genome sequence of Tribolium castaneum. Eleven genes encoding cadherin proteins have been annotated, all closely related to other insect cadherins. The predicted structures of the Tribolium cadherins are discussed with respect to proposed function.