Submitted to: Meeting Abstract
Publication Type: Abstract Only
Publication Acceptance Date: 9/22/2005
Publication Date: 9/22/2005
Citation: Wang, Y., Uthe, J.J., Bearson, S.M., Qu, L., Nettleton, D., Tuggle, C.K. 2005. Identification of differentially expressed genes in response to infection to host-specific and host-generalist Salmonella enterica serotypes in pigs [abstract]. Integration of Structural and Functional Genomics Symposium. p. 23. Interpretive Summary:
Technical Abstract: Salmonellosis is prevalent worldwide and most Salmonella serotypes have a broad host range. Two classic salmonella species infecting pigs are S. enterica serotype Choleraesuis (SC) and S. enterica serotype Typhimurium (ST), the latter of which can also infect humans. The former can cause septicemia, enterocolitis, pneumonia, and/or hepatitis, whereas the latter only results in mild enterocolitis. Understanding the porcine systemic transcriptional response to SC and ST has significance for both animal disease resistance and human food safety. In this study, the porcine Affymetrix microarray chips, which contains 23,937 probe sets were used to investigate the differential transcript response to infection to host-specific and host-generalist Salmonella enterica serotypes in pigs.