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United States Department of Agriculture

Agricultural Research Service


item Karnsakul, Wikrom
item Kitagawa, Seiji
item Olive, Anthomy
item Villa, Xavier
item Sterchi, Erwin
item Hahn, Dagmar
item Lugenbuehl, Ursi
item Nichols, Buford

Submitted to: Pediatric Research
Publication Type: Abstract only
Publication Acceptance Date: 3/1/2001
Publication Date: 4/1/2001
Citation: Karnsakul, W., Kitagawa, S., Olive, A., Villa, X., Sterchi, E.E., Hahn, D., Lugenbuehl, U., Nichols, B.L. 2001. Frequency of disaccharidase deficiencies in childhood chronic abdominal pain. Pediatric Research. 49:118A.

Interpretive Summary: Interpretive Summary not needed for this 115.

Technical Abstract: BACKGROUND: Recurrent abdominal pain and discomfort are common symptoms in children. Childhood chronic abdominal pain (CCAP) is a poorly understood condition, which occasionally requires EGD. Endoscopy is performed to search for etiologies such as peptic ulcer disease. Lactose and sucrase-isomaltase deficiencies are known to cause diet associated abdominal complaints in some children. Disaccharide loading H2 breath tests of CCAP have yielded inconclusive results. OBJECTIVE: To determine frequency of disaccharidase deficiencies in CCAP. DESIGN/METHODS: Patients with abdominal pain for at least one month came were endoscoped. Enzyme assays were performed on jejunal biopsies with a modified Dahlqvist method using Polycose, sucrose, lactose, and maltose as substrates. Each study subject had normal villus length and villus-crypt ratio without increase of theliolymphocytes (Shiner criteria of <23%). RESULTS: Forty-one CCAP patients were endoscoped (47% F, 53% M; aged 11+/- 5 years). Low disaccharidase levels were found in 30%. Six had combined glucoamylase, sucrase, and lactase deficiencies (pandisaccharidase deficiencies). One had combined glucoamylase and sucrase deficiencies; five had isolated lactase deficiencies; and one had isolated sucrase deficiency. CONCLUSIONS: 30% of patients endoscoped for CCAP had one or more disaccharidase deficiencies. Pandisaccharidase deficiencies were present in half of this subgroup. Disaccharidase deficiencies may contribute to gastrointestinal complaints of 30% CCAP patients. Pandisaccharidase deficiencies may account for some of the difficulties in dietary management of CCAP.

Last Modified: 8/24/2016
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