Submitted to: Meeting Abstract
Publication Type: Abstract Only
Publication Acceptance Date: 8/6/2005
Publication Date: 9/10/2005
Citation: Chun, H., Lee, S., Cho, S., Chung, H., Park, H., Cho, S., Lee, Y., Lillehoj, H.S. 2005. Effects of dietary phytic acid on the serum lipid levels in aged mice.Proceedings of International Symposium on Triglycerides, p. 21. Interpretive Summary:
Technical Abstract: Aging is a multi-factorial phenomenon. There are several clinical conditions directly related to the lipid metabolism that induces hypertriglycemia, hypercholesterolemia and cardiovascular disease during aging. There is a large body of evidence showing that triglyceride, cholesterol and LDL-cholesterol are among the major risk factors for cardiovascular disease, while HDL-cholesterol level is inversely correlated with such a risk. Attention has been focused on possible intervention strategies to control the levels of serum lipid, such as triglyceride, total cholesterol, LDL- or HDL-cholesterol. Phytic acid is a plant component which exists in most grains and legumes, the main source of the calorie intake for the old, and much research has been done on the antioxidant and antinutrient effects of phytic acid in the growing animal model. But its effect on the lipid profiles in the aged model has not been evaluated yet. The study was carried out to investigate the effect of phytic acid on the lipid levels in the serum of aged mice. Forty aged ICR male mice were fed with purified diets supplemented with 0 (PO), 0.5 (P5), 1.0 (PIO), and 1.5 % (PIS) sodium phytate for 12 weeks. Diet intake, body and organ weights, and contents of serum and fecal lipid profiles were measured. There were no significant differences in diet intake, body weight, organ weight and serum total cholesterol levels among experimental groups. The concentrations of the serum triglyceride and LDL-cholesterol were lower in the groups fed phytate diets than the POgroup. Serum HDL-cholesterollevels of the groups fed phytate diets were higher than the POgroup. The contents of fecal total lipid and total cholesterol were higher in the PIO and the PIS groups. These results suggested that phytic acid affect the serum lipid levels in aged mice by increasing their fecal lipid levels.