Submitted to: Elsevier
Publication Type: Book / chapter
Publication Acceptance Date: 7/20/2003
Publication Date: 2/15/2005
Citation: Davis, T.A., Fiorotto, M.L. 2005. Regulation of skeletal muscle protein metabolism in growing animals. In: Burrin, D.G., Mersmann, H.J., Salek, E., editors. Biology of Metabolism in Growing Animals. Biology of Growing Animals Series, Volume 3. London, United Kingdom:Elsevier Limited. Part II: Protein Metabolism, Chapter 2, p. 37-68. Interpretive Summary: No Interpretive Summary Needed for Book Chapter.
Technical Abstract: The skeletal musculature is not only of great significance to the physiological function and long-term well-being of the growing animal, but, by virtue of its large mass, has tremendous impact on the overall rate of protein metabolism in the whole body. Protein deposition is very rapid during early life and this is largely driven by the high fractional rate of protein synthesis in skeletal muscle. A number of factors regulate the growth, development, and metabolic activity of the skeletal musculature, and these include the intrinsic or genetic factors that influence muscle differentiation as well as the extrinsic factors such as nutrients, hormones, and activity that influence muscle hypertrophy.