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Title: MOLECULAR CHARACTERIZATION OF THE MAREK'S DISEASE VIRUS VHS GENE (UL41)

Author
item Silva, Robert
item Gimeno, Isabel

Submitted to: American Veterinary Medical Association Abstract
Publication Type: Abstract Only
Publication Acceptance Date: 7/16/2005
Publication Date: 7/16/2005
Citation: Silva, R.F., Gimeno, I.M. 2005. Molecular characterization of the Marek's disease virus vhs gene (UL41)[abstract]. American Veterinary Medical Association. p. 49.

Interpretive Summary:

Technical Abstract: Herpesviruses use multiple means to help them evade host defenses. One method is through a herpesvirus gene product called virion host shutoff protein (vhs). vhs causes a rapid shutoff of all host proteins. The Marek's disease virus (MDV) UL41 gene is a homolog of the herpes simplex virus vhs. To investigate whether the MDV UL41 functions as a vhs, we characterized the MDV UL41 gene. We will present data on the cloning, expression and deletion of the MDV UL41 gene.