Submitted to: Meeting Abstract
Publication Type: Proceedings
Publication Acceptance Date: 3/18/2005
Publication Date: 7/1/2005
Citation: Liu, Z., Slininger, P.J. 2005. Transcriptome dynamics of ethanologenic yeast in response to 5-hydroxymethylfurfural stress related to biomass conversion to ethanol [abstract]. Abstract Book. p. 991.
Technical Abstract: Over 200 genes were identified as significantly affected by 5-hydroxymethylfurfural to ethanologenic yeast among 6,388 genes of Saccharomyces cerevisiae (P less than or equal to 0.05). Transcriptome dynamics of the identified genes were described during the course of fermentation. Genes in a wide range of functional categories showed distinct patterns of expression compared with that of the control under normal conditions. Results of this study strongly suggested that cells of the ethanologenic yeast went through an adaptation process at the genome level and showed altered metabolic activities to cope with the HMF stress at the earlier cell growth phase.