Skip to main content
ARS Home » Research » Publications at this Location » Publication #177534
Title: BIOLOGICAL CHARACTERIZATION OF A MUTANT MAREK'S DISEASE VIRUS LACKING THE UL41 GENE (RMD5DUL41)

Author
item Gimeno, Isabel
item Silva, Robert

Submitted to: American Veterinary Medical Association Abstract
Publication Type: Abstract Only
Publication Acceptance Date: 7/16/2005
Publication Date: 7/16/2005
Citation: Gimeno, I.M., Silva, R.F. 2005. Biological characterization of a mutant Marek's disease virus lacking the UL41 gene (RMD5DUL41)[abstract]. American Veterinary Medical Association. p. 48.

Interpretive Summary:

Technical Abstract: A virion host shutoff (vhs) gene has been described in various herpesviruses. In particular, the herpes simplex virus (HSV) UL41 gene has been well characterized and its role on HSV pathogenesis is well understood. Marek's disease virus (MDV) UL41 gene is a homologous of the HSV UL41 gene but its biological function is unknown. The aim of this study was to utilize a mutant MDV (rMd5dUL41) lacking the UL41 gene to characterize the biological function of UL41 gene. The role of UL41 gene on MDV replication, transmission, neurovirulence, transformation and viral regulation of latency, reactivation and immune response is presented.