Submitted to: Meeting Abstract
Publication Type: Abstract Only
Publication Acceptance Date: 2/21/2005
Publication Date: 5/20/2005
Citation: Zarlenga, D.S. 2005. Recombinant parasite vaccines. the good, the bad and the ugly. [abstract]. Fourth International Workshop on Novel Approaches to Control Helminth Parasite of Livestock. Paper #27. Interpretive Summary:
Technical Abstract: As a direct consequence of rising drug resistance among common nematodes of grazing animals, efforts toward state-of-the-art vaccine development have clearly intensified in recent years, fuelled primarily by the advent of newer technologies in gene discovery, and by advancements in antigen identification, characterization and production. In this regard, it is appropriate to review progress that has been made in generating helminth vaccines and in particular, vaccines against common nematodes of food animals. In like manner, it is prudent to evaluate barriers that have hindered progress in the past and continue to present obstacles that must be bridged when utilizing and depending on host immunity to attenuate parasitic infections.