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United States Department of Agriculture

Agricultural Research Service


item Cottrell, Jeremy
item Stoll, Barbara
item Buddington, Randy
item Riedijk, Maaike
item Stephens, John
item Cui, Liwei
item Chang, Xioyan
item Burrin, Douglas - Doug

Submitted to: Journal of Federation of American Societies for Experimental Biology
Publication Type: Abstract only
Publication Acceptance Date: 1/1/2005
Publication Date: 4/1/2005
Citation: Cottrell, J., Stoll, B., Buddington, R., Riedijk, M., Stephens, J., Cui, L., Chang, X., Burrin, D.G. 2005. GLP-2 treatment during chronic tpn improves intestinal glucose uptake after re-feeding in piglets. Journal of Federation of American Societies for Experimental Biology. 19:A1695.

Interpretive Summary: Interpretive Summary not needed for this 115.

Technical Abstract: Intestinal atrophy and lower nutrient absorption caused by chronic total parenteral nutrition (TPN) compromises the transition to enteral feeding. We examined whether providing glucagon-like peptide 2 (GLP-2) during TPN improved this transition by comparing neonatal piglets maintained for 7 d on enteral formula (ENT), TPN and TPN with GLP-2 (500 pmol/kg/h) and then provided for 6-h with an enteral formula. GLP-2 partially protected against the TPN induced loss in intestinal weight (50a, 29b, 38c g/kg for ENT, TPN, GLP-2), villus height (1199a, 405b, 809c 'm), and total intestinal lactase activity (7703a, 2568b, 4404c mmol/min). Providing GLP-2 increased in vitro rates of glucose transport compared to TPN alone (Vmax = 4.08a, 1.76b, 3.25c nmol/mg-min), consistent with higher total glucose transport capacity. The improved uptake capacity was reflected by improved in vivo net portal glucose (97a, 58b, 31c% of intake) and galactose absorption (57a, 27b,51a %), despite lower portal blood flow in the GLP-2 group compared to the TPN group (4.31ab, 4.88a, 3.62ab L/kg/h). Mucosal lactate production in the GLP-2 group was intermediate between ENT and TPN (0.33a, 1.44b, 0.92ab mmol/kg/h). We conclude that providing GLP-2 during chronic TPN improved intestinal digestive and absorptive capacity parallel with improvements in mucosal structure. Therefore, it is likely that GLP-2 will augment the transition to enteral feeding.

Last Modified: 8/24/2016
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