Submitted to: Journal of Natural Products
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: 11/19/2004
Publication Date: 1/15/2005
Citation: Angawi, R.F., Swenson, D.C., Gloer, J.B., Wicklow, D.T. 2005. Malettinins B-D: New polyketide metabolites from an unidentified fungal colonist of Hypoxylon stromata (NRRL 29110). Journal of Natural Products. 68:212-216. Interpretive Summary: Fungi that parasitize and kill other fungi offer a potential source of new bioactive agents useful to agriculture and medicine. An unidentified fungus, encountered as a colonist of the persistent fruit body of the wood-decay fungus Hypoxylon, was examined for its ability to produce novel bioactive metabolites. Malettinins B-D are reported as new fungal metabolites with unique fungal structures and showing antifungal activity in assays against Candida albicans and/or antibacterial activity against Staphylococcus aureus and Bacillus subtilis. These results will benefit agriculture and medicine by offering novel lead compounds with antimicrobial activity, information that can be used to guide the synthesis of antibiotics or fungicides.
Technical Abstract: Malettinins B-D, three new antimicrobial polyketide-derived metabolites related to the previously reported malettinin A (1), have been obtained from non-sporulating cultures of an isolate of Mycelia sterilia MYC-155 (=NRRL 29110) collected from colonies of Hypoxylon stromata. Malettinins B (2) and C (3) are partially reduced analogs of malettinin A, and were identified by analysis of NMR and MS data. Malettinin D is biogenetically similar, but possesses a new ring system, and the structure was established by single-crystal X-ray diffraction analysis.