Submitted to: Western Poultry Disease Conference
Publication Type: Proceedings
Publication Acceptance Date: 2/1/2005
Publication Date: 4/25/2005
Citation: Pantin Jackwood, M.J., Spackman, E., Day, J.M. 2005. Comparison of bursal histology lesions caused by different isolates of turkey reovirus.Proceedings of Western Poultry Disease Conference, p. 126. Interpretive Summary:
Technical Abstract: Microscopic lesions in the bursa of Fabricius from specific pathogen free poults inoculated with four different turkey origin reovirus isolates (TRV'S) were compared. These reovirus isolates were collected from commercial turkeys that had enteritis. SPF poults were inoculated at 3 days post-hatch and bursa, thymus, liver, spleen, heart, pancreas, duodenum, jejunum, and ceca from each bird were collected at 2, 5, 7, and 9 days post inoculation for histopatologic examination and IHC. The most important lesion associated with TRV infection in poults occurred in the bursa. All TRV's studied, induced different degrees of bursal atrophy characterized by moderate to severe lymphoid depletion and increased fibroplasia between the follicles. One isolate induced particularly severe lesions in the bursa, and multiple intrafollicular cysts were present at 5, 7, and 9 days post inoculation. Viral antigen was detected mainly in macrophages in the bursa. The damage present in the bursa would most likely result in immune dysfunction in poults infected with TRV.