Submitted to: American Chemical Society Symposium Series
Publication Type: Book / chapter
Publication Acceptance Date: 1/10/2005
Publication Date: 5/25/2006
Citation: Kagan, I., Michel, A., Scheffler, B.E., Prause, A., Baerson, S.R., Duke, S.O. Global gene expression approaches to mode-of-action studies with natural product-based pesticides. Rimando, A.M., Duke, S.O., editors. American Chemical Society, Washington, DC. Natural Products for Pest Management. 2006. pp. 255-264. Interpretive Summary:
Technical Abstract: Natural products represent a vast repository of potential pesticides, some with novel molecular target sites. Whole-genome DNA microarrays seem a promising tool for identifying novel target sites, as microarrays enable monitoring the effects of a toxicant on the expression of every gene of an organism, providing clues about the targeted pathway or process. Examples of microarray studies of fungicide effects on Saccharomyces cerevisiae (baker's yeast), and of the effects of a natural herbicide on the dicot Arabidopsis thaliana, are presented. The results support a role for microarray studies in identifying molecular target sites and understanding the responses of plants to xenobiotics.