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ARS Home » Northeast Area » Boston, Massachusetts » Jean Mayer Human Nutrition Research Center On Aging » Research » Publications at this Location » Publication #171920
Title: PREDICTING THE FAILURE OF AMYLOID-BETA VACCINE

Author
item SMITH, MARK - CASE WESTERN RESERVE UNIV
item ATWOOD, CRAIG - CASE WESTERN RESERVE UNIV
item Joseph, James
item PERRY, GEORGE - CASE WESTERN RESERVE UNIV

Submitted to: Lancet
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: 4/5/2002
Publication Date: 5/25/2002
Citation: Smith, M.A., Atwood, C.S., Joseph, J.A., Perry, G. 2002. Predicting the failure of amyloid-beta vaccine. Lancet. 359:1864-1865.

Interpretive Summary:

Technical Abstract: This correspondence discusses the failure of the amyloid-Beta vaccine for treatment of Alzheimer's disease (AD). The authors argue that there is no evidence to suggest that the removal or alteration of amyloid-beta deposits would benefit patients with AD. Instead it is proposed that the removal of amyloid-beta from the brain of the aged or those with AD is more likely to destabilize age-related or disease-related compensations and be harmful, as seen in the testing of the amyloid-Beta vaccine.