Submitted to: Journal of Animal Science
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: 10/9/1997
Publication Date: N/A
Citation: Splan, R.K., Pilcik, B.R., Tomsen, U.J., Arango, J.A., Ruiz-Flores, A., Hallock, J.W., Allan, M.F., Karnati, S.K., Vega, V., Lindsey, B.R., Moody, D.E., Pomp, D. 1998. Rapid communication: Mapping of the steroidogenic acute regulatory protein (StAR) gene to porcine chromosome 15 by linkage analysis using a novel PCR-RFLP. Journal of Animal Science. 76(2):658-659. Interpretive Summary: Steriodogenic acute regulatory protein (StAR) has a rate-limiting role in steroidogenesis by enhancing the conversion of cholesterol into one of the needed substrates for the production of steroids. Because of this role StAR becomes a potential gene candidate for reproduction in livestock. Mapping of StAR to swine chromosome 15 also defines a new homology with human Chromosome 8. This homology among species will be helpful with comparative map efforts across species.
Technical Abstract: Steroidogenic acute regulatory protein has a rate-limiting role in steroidogenesis by enhancing the metabolism of cholesterol into pregnenolone and may be an excellent candidate gene for controlling reproduction phenotypes. Preliminary evidence in swine found a QTL affecting ovulation rate on SSC15, in the general region where StAR is harbored. The StAR gene has recently been mapped to human chromosome 8p11.2 (HSA8; GDB accession number 635457). Of the genes previously mapped to SSC15 (DPP4, EAG, GAD1, LCT, and LRP2), several are assigned to HSA2 but none have assignments on HSA8. Mapping of StAR to SSC15, therefore, defines a new homology (HSA8 and SSC15) in the comparative map between human and pig, and may identify an evolutionary breakpoint between HSA2 and HSA8 in relation to pigs.