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Title: MALETTININ A: A NEW ANTIFUNGAL TROPOLONE FROM AN UNIDENTIFIED FUNGAL COLONIST OF HYPOXYLON STROMATA (NRRL 29110)

Author
item ANGAWI, RIHAB - U OF IA, IOWA CITY, IA
item SWENSON, DALE - U OF IA, IOWA CITY, IA
item GLOER, JAMES - U OF IA, IOWA CITY, IA
item Wicklow, Donald

Submitted to: Tetrahedron Letters
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: 8/15/2003
Publication Date: 9/20/2003
Citation: Angawi, R.F., Swenson, D.C., Gloer, J.B., Wicklow, D.T. 2003. Malettinin A: a new antifungal tropolone from an unidentified fungal colonist of Hypoxylon stromata (NRRL 29110). Tetrahedron Letters. 44:7593-7596.

Interpretive Summary: Fungi that parasitize and kill other fungi offer a potential source of new bioactive agents useful to agriculture and medicine. An unidentified fungus, encountered as a colonist of the persistent fruit body of the wood-decay fungus Hypoxylon, was examined for its ability to produce novel bioactive metabolites. Malettinin A is reported as a new fungal metabolite with a unique fungal structure and potent antifungal activity against Aspergillus flavus, a toxin producing fungal pathogen of corn kernels.

Technical Abstract: Malettinin A (1) has been isolated from cultures of an unidentified fungus encountered as a colonist of Hypoxylon stromata. The structure 1 was proposed by analysis of NMR and MS data, and confirmed by X-ray diffraction analysis of a methanol adduct. Malettinin A shows significant activity in assays against Aspergillus flavus.