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ARS Home » Southeast Area » Little Rock, Arkansas » Microbiome and Metabolism Research Unit » Research » Publications at this Location » Publication #166780
Title: ASSESSMENT OF PROTEIN ALLERGENICITY ON THE BASIS OF IMMUNE REACTIVITY: ANIMAL MODELS

Author
item KIMBER, IAN - SYNGENTA CENTRAL TOX. LAB
item DEARMAN, REBECCA - SYNGENTA CENTRAL TOX. LAB
item PENNINKS, ANDRE - TNO NUTRITION & FOOD RES
item KNIPPELS, LE - TNO NUTRITION & FOOD RES
item BUCHANAN, ROBERT - UNIV OF CA, BERKELEY
item HAMMERBERG, BRUCE - UNIV OF CA, BERKELEY
item JACKSON, HILARY - N CAROLINA STATE UNIV
item HELM, RICKI - UAMS

Submitted to: Environmental Health Perspectives
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: 5/15/2003
Publication Date: 6/17/2003
Citation: Kimber, I., Dearman, R.J., Penninks, A.H., Knippels, L., Buchanan, R.B., Hammerberg, B., Jackson, H.A., Helm, R.M. 2003. Assessment of protein allergenicity on the basis of immune reactivity: animal models. Environmental Health Perspectives. 111(8):1125-30.

Interpretive Summary: Because of the public concern surrounding the issue of the safety of genetically modified organisms, it is critical to have appropriate methodologies to aid investigators in identifying potential hazards associated with consumption of foods produced with these materials. A recent panel of experts convened by the Food and Agriculture Organization and World Health Organization suggested there is scientific evidence that using data from animal studies will contribute important information regarding the allergenicity of foods derived from biotechnology. This view has given further impetus to the development of suitable animal models for allergenicity assessment. This article is a review of what has been achieved and what still has to be accomplished regarding several different animal models. Progress made in the design and evaluation of models in the rat, the mouse, the dog and in swine is reviewed and discussed

Technical Abstract: Because of the public concern surrounding the issue of the safety of genetically modified organisms, it is critical to have appropriate methodologies to aid investigators in identifying potential hazards associated with consumption of foods produced with these materials. A recent panel of experts convened by the Food and Agriculture Organization and World Health Organization suggested there is scientific evidence that using data from animal studies will contribute important information regarding the allergenicity of foods derived from biotechnology. This view has given further impetus to the development of suitable animal models for allergenicity assessment. This article is a review of what has been achieved and what still has to be accomplished regarding several different animal models. Progress made in the design and evaluation of models in the rat, the mouse, the dog and in swine is reviewed and discussed. Key words: allergy, dog, hazard identification, IgE, IgG, immunogenicity, mouse, rat, risk assessment, swine.