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Title: INTERACTION OF AMINO ACIDS AND INSULIN IN THE REGULATION OF PROTEIN METABOLISM IN GROWING ANIMALS

Author
item Davis, Teresa
item SURYAWAN, AGUS - BAYLOR COLL OF MEDICINE
item BUSH, JILL - BAYLOR COLL OF MEDICINE
item O'CONNOR, PAMELA - BAYLOR COLL OF MEDICINE
item THIVIERGE, M. CAROLE - UNIVERSITE LAVAL, CANADA

Submitted to: Canadian Journal of Animal Science
Publication Type: Review Article
Publication Acceptance Date: 3/28/2003
Publication Date: 10/2/2003
Citation: Davis, T.A., Suryawan, A., Bush, J.A., O'Connor, P.M., Thivierge, M.C. 2003. Interaction of amino acids and insulin in the regulation of protein metabolism in growing animals. Canadian Journal of Animal Science. 83(3):357-364.

Interpretive Summary: Not necessary for a Review

Technical Abstract: Young animals utilize their dietary amino acids more efficiently for growth because they are capable of a greater increase in tissue protein synthesis in response to feeding than older animals. This response to feeding is particularly profound in skeletal muscle. The feeding-induced stimulation of protein synthesis in skeletal muscle is uniquely and independently regulated by both insulin and amino acids. In most visceral tissues, the stimulation of protein synthesis by feeding is mediated by amino acids alone and not by insulin. The stimulation of protein synthesis by nutrition and hormones is regulated by alterations in the expression and activity of components of the intra-cellular signaling pathways that control the initiation of translation.