Author
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Prior, Ronald |
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Submitted to: Review Article
Publication Type: Review Article Publication Acceptance Date: 5/16/2004 Publication Date: 7/20/2004 Citation: Prior, R.L. 2004. Biochemical measures of antioxidant status. Topics in Clinical Nutrition. 19(3):226-238. Interpretive Summary: Oxidative stress and damage in tissues may be directly or indirectly involved in many pathological processes. Oxidative damage is generally assessed by measurement of secondary oxidation products. Antioxidant status can be assessed by measuring individual plasma or tissue levels of antioxidants and/or by using measures of antioxidant capacity. Clinical studies must include multiple biomarkers in order to adequately assess in vivo antioxidant status and oxidative stress. This review focuses on noninvasive biomarkers of radical-induced damage in biological tissues and fluids and other biomarkers of antioxidant status. Technical Abstract: Oxidative stress (OS) results from a disruption of cellular prooxidant/antioxidant balance due to reactive oxygen species (ROS) and other radicals and oxidants, and may be directly or indirectly involved in many pathological processes. Direct detection of ROS and other radicals is difficult. Oxidative damage is generally assessed by measurement of secondary oxidation products. Antioxidant status can be assessed by measuring individual plasma or tissue levels of antioxidants and/or by using measures of antioxidant capacity. Clinical studies must include multiple biomarkers in order to adequately assess in vivo antioxidant status/OS. This review will focus on noninvasive biomarkers of radical-induced damage in biological tissues and fluids and other biomarkers of antioxidant status. |
