|Kehrli Jr, Marcus|
Submitted to: Comparative Medicine
Publication Type: Review Article
Publication Acceptance Date: 3/30/2004
Publication Date: 8/31/2004
Citation: Gu, Y., Bauer, T.R., Ackermann, M.R., Smith, W.C., Kehrli Jr, M.E., Starost, M.F., Hickstein, D.D. 2004. The genetic immunodeficiency disease leukocyte adhesion deficiency in man, dog, cattle, and mouse. Comparative Medicine. 54:363-372. Interpretive Summary: Not required for a review article.
Technical Abstract: This review highlights the genotype-phenotype relationship of the genetic immunodeficiency disease leukocyte adhesion deficiency (LAD) in man, dog, cattle, and mouse, and provides an assessment of the opportunities that each animal species provides in understanding leukocyte biology and in developing new therapeutic approaches to LAD in humans. This comparison is important since animal models of genetic diseases in humans provide the opportunity to test new therapeutic approaches in an appropriate disease-specific model prior to their translation to humans. The success of this approach is directly dependent upon the relationship of the phenotype in the animal to the phenotype of the disease in humans.