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United States Department of Agriculture

Agricultural Research Service


item Garcia, Jarrod
item Schmidt, Ty
item Berg, Eric
item Cochran, Eric
item Kleiboeker, Steve
item Morgan, Canaan
item Drager, Cody
item Carroll, Jeffery - Jeff Carroll
item Keisler, Duane
item Larson, Robert
item Olson, K
item Rentfrow, Greg
item Brown, Mike

Submitted to: American Society of Animal Science Annual Meeting
Publication Type: Abstract Only
Publication Acceptance Date: 4/12/2004
Publication Date: 7/23/2004
Citation: Garcia, J.J., Schmidt, T.B., Berg, E.P., Cochran, E.M., Kleiboeker, S.B., Morgan, C.W., Drager, C.D., Carroll, J.A., Keisler, D.H., Larson, R., Olson, K.C., Rentfrow, G., Brown, M.S. 2004. Dietary supplementation of lipoic acid and its effect on circulating metabolic hormones and acute phase proteins of virus-challenged beef steers. American Society of Animal Science Annual Meeting. Journal of Animal Science. 82(1):407.

Interpretive Summary:

Technical Abstract: To determine the effect of lipoic acid (LA) supplementation on circulating metabolic hormones and acute phase proteins of virus challenged steers, 32 cross-bred steers (BW=308+/-27kg) were randomly assigned to control (CON), LA supplemented at 16mg/kg of BW (LA16), LA at 32 mg/kg of BW (LA32), and a negative control (NEG) treatments. Steers were allowed a 21 d adaptation period to adjust to treatment and environment. On d 22, blood samples, nasal swabs, BW, DMI, and rectal temperature were recorded. Control, LA16, and LA32 steers all received an intra-nasal dose of 2 ml/nostril of infectious bovine respiratory virus (Cooper stain, 1 X 10^6-7 PFU); NEG received a 2 ml/nostril saline dose. Blood samples, nasal swabs, BW, DMI, and rectal temperatures were collected on 23, 25, 27, 29, 36, and 43 d. Serum samples were analyzed for haptoglobin, amyloid-A, leptin, insulin, and serum-neutralization titer levels. Prior to challenge, DMI as percentage of BW was similar for all four treatments. Seven and 14 d post-challenge, DMI of LA32 was higher (P<0.05) than CON and LA16 (DMI as % BW; 1.35-7 d; 1.88-14 d vs. 0.95-7 d; 1.77-14 d, and 0.95-7 d; 1.67-14 d, respectively). As for maintaining body weight after viral challenge, all treatment groups experience BW loss. However by d 29, LA32 had rebounded and was gaining BW (+5.15 kg from previous BW; P<0.001), while NEG, CON, and LA16 continued to experience decreased BW (-3.45, -1.59, and -1.42 kg from previous BW, respectively). Haptoglobin concentrations were similar between all treatments pre-challenge (0.147, 0.133, 0.121, and 0.128 ng/ml for CON, LA16, LA32, and NEG, respectively). On d 27, LA32 had lower (P<0.04) serum concentrations compared to CON (0.311 vs. 0.592 ng/ml), and lower than CON and LA16 on d 29. Haptoglobin concentrations were at or below pre-challenge concentrations by d 36. Serum-neutralization titers for 30/32 steers were negative on d 22. However, by d 43 all animals were positive for IBRV antibodies. The geometric mean titer for LA32 was greater (P<0.001) compared to CON, LA16, and NEG (2^105, 2^25, 2^39, and 2^59, respectively). Results indicate that supplementation of LA at 32 mg/kg of BW can provide additional protection to steers facing a viral challenge associated with respiratory disease.

Last Modified: 07/23/2017
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