Submitted to: International Marek's Disease Symposium Abstracts and Proceedings
Publication Type: Abstract only
Publication Acceptance Date: 7/14/2004
Publication Date: 7/14/2004
Citation: Hunt, H.D. 2004. A new paradigm for the mechanism of Marek's disease vaccination [abstract]. International Marek's Disease Symposium Abstracts and Proceedings. Paper No. P. 3. Interpretive Summary:
Technical Abstract: The mechanism of highly effective vaccines that inhibit MDV induced T cell tumor induction is unknown. The proposed mechanism, or mechanisms, must account for the fact that MDV vaccines can be administered to 18-day-old embryonated eggs, which, 3 days later, then protects the hatched chicken from an oncogenic MDV challenge within 3-5 days of vaccination. Two diametrically opposed hypotheses have been suggested to explain this phenomenon. The first hypothesis suggests that first innate and then acquired cellular immunity is induced by vaccination, which affords protection to the development of T cells tumors. The second hypothesis suggests that vaccination, through some unknown mechanism, reduces the number of CD4 T cells available for MDV infection and thus reduces the statistical chance for tumor induction. A theory is presented to integrate the host virus interactions observed in Marek's disease vaccination.