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ARS Home » Northeast Area » Boston, Massachusetts » Jean Mayer Human Nutrition Research Center On Aging » Research » Publications at this Location » Publication #161633
Title: GOLDEN-SYRIAN HAMSTER AS A MODEL OF DIET INDUCED CHANGES IN LIPOPROTEIN METABOLISM

Author
item DORFMAN, SUZANNE - TUFTS-HNRCA
item SMITH, DONALD - TUFTS-HNRCA
item OSGOOD, DOREEN - ENDOCRIN/DIAB RSRCH LAB
item LICHTENSTEIN, ALICE - TUFTS-HNRCA

Submitted to: Journal of Nutrition
Publication Type: Research Notes
Publication Acceptance Date: 9/10/2003
Publication Date: 12/1/2003
Citation: DORFMAN, S.E., SMITH, D.E., OSGOOD, D.P., LICHTENSTEIN, A.H. GOLDEN-SYRIAN HAMSTER AS A MODEL OF DIET INDUCED CHANGES IN LIPOPROTEIN METABOLISM. JOURNAL OF NUTRITION. 2003;133:4183-8.

Interpretive Summary:

Technical Abstract: The objective of this study was to characterize two strains of Golden-Syrian hamsters for use in the study of diet induced changes in lipoprotein metabolism. In Experiment 1, the time course and response to dietary saturated fat was investigated for serum lipoprotein profiles and aortic lesion formation in Golden-Syrian hamsters from Charles River Laboratories, Wilmington, MA (CR) and Bio Breeders Inc., Watertown, MA (F1B). Hamsters were fed a chow-based diet containing 10% saturated fat (w/w) and 0.1% cholesterol (w/w). After 12 weeks, CR hamsters had significantly lower serum total and non-high density lipoprotein cholesterol (TC and nHDL-C) levels, but higher aortic cholesteryl ester (CE), than the F1B hamsters (P < 0.05). In Experiment 2, CR hamsters were fed a chow-based diet containing 10% saturated fat and either 0.1%, 0.5% or 1.0% cholesterol. After 10 weeks of dietary intervention, TC and nHDL-C levels were significantly higher in the 0.5% and 1.0% cholesterol than 0.1% cholesterol group. These levels declined after 20 weeks of dietary intervention in all groups, potentially reflecting the toxic effect of high cholesterol intakes. CR hamsters fed a 10% saturated fat containing 0.1% dietary cholesterol for 10 weeks appears to be a good model for investigating diet induced change in plasma lipids.