Submitted to: American Association of Immunologists Proceedings
Publication Type: Abstract only
Publication Acceptance Date: 4/10/2004
Publication Date: 5/2/2004
Citation: Lillehoj, H.S., Min, W. 2004. High-throughput gene expressiion profiling of host intstinal immune response to eimeria.. American Association of Immunologists Proceedings p. 212. Interpretive Summary:
Technical Abstract: Avian coccidiosis is caused by several Eimeria strains which infect different regions of the intestine inducing a strain-specific immunity. Coccidiosis usually stimulate a number of immunological defense mechanisms, namely both antibody- and cell-mediated. Recent technological advances in high-throughput molecular approaches to identify disease resistance genes and molecular/cell biological pathways associated with complex biological phenomenon now enable a comprehensive investigation of host protective immune mechanisms. Our recent studies on local host immunity to Eimeria clearly indicate that intricate and complex interactions of host local cell-mediated immunity and parasites determine the outcome of host response to coccidiosis. High-throughput gene expression profiling and real-time PCR have been applied to analyze underlying immune mechanisms controlling disease resistance/susceptibility to coccidiosis. The results indicate role of various cytokines in controlling host intestinal innate immune response to Eimeria.