Submitted to: American Physical Society
Publication Type: Abstract only
Publication Acceptance Date: 3/23/2004
Publication Date: 3/23/2004
Citation: Barone, J.R., Schmidt, W.F. 2004. Molecular conformational changes in cartilage using NMR spectroscopy [abstract]. American Physical Society. Paper No. L31.010. Interpretive Summary:
Technical Abstract: NMR spectroscopy is used to study the conformational changes of the collagen and glycosaminoglycan molecules in bovine articular cartilage. Molecular conformation will change with the charge on each molecule. The charge on each molecule varies spatially throughout the cartilage. For a given point in space, the charge on each molecule can be screened by placing the cartilage in an increasingly ionic environment. The conformational changes are noted through changes in the chemical shifts in the NMR spectrum as a function of salt concentration.