|Bryden, Noella - Noel|
Submitted to: Meeting Abstract
Publication Type: Abstract Only
Publication Acceptance Date: 11/25/2003
Publication Date: 4/1/2004
Citation: Roussel, A., Bureau, I., Arnaud, J., Faure, H., Bryden, N.A., Anderson, R.A. 2004. Alterations of micronutrient and mineral status in postmenopausal women with and without hrt [abstract]. Federal Association Society of Experimental Biology Journal. 18(118.6):A134. Interpretive Summary:
Technical Abstract: Modifications of micronutrient and mineral status are involved in most of the menopause-related pathologies. The aim of this study was to investigate the modifications of plasma and urinary trace element concentrations, urinary mineral excretion, and plasma vitamin levels in postmenopausal women (PMW) receiving or not hormone replacement therapy (HRT) compared with premenopausal women. Eighteen PMW were treated by combined HRT for at least two years and 26 were untreated. In PMW without HRT vs premenopausal women, plasma antioxidant vitamin levels were unchanged. In contrast, plasma copper decreased and urinary losses of Zn, Cr, Mg and Ca significantly increased. In women receiving HRT, beneficial effects of the treatment were observed for trace elements and minerals compared with untreated PMW. Plasma Cu and Cr were significantly higher in treated PMW than in untreated women whereas urinary Cr excretion was decreased. Urinary Zn, Mg and Ca losses were lower in treated women than in women without HRT. In contrast, women receiving HRT had lower levels of plasma vit C, ß-carotene and vit E. In summary, HRT contributes to beneficial effects in improving Cr status and decreasing urinary losses of Zn, Mg and Ca. However, an adverse effect of HRT was observed regarding plasma antioxidant vitamin levels. These data should be considered in nutritional recommendations for women receiving HRT.