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United States Department of Agriculture

Agricultural Research Service


item Seo, Jung
item Lee, Kyeung
item Jang, Jung
item Zhejiu, Quan
item Yang, Kyung
item Burri, Betty

Submitted to: Nutrition Research
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: 8/13/2004
Publication Date: 9/24/2004
Citation: Seo, J.S., Lee, K.S., Jang, J.H., Zhejiu, Q., Yang, K.M., Burri, B.J. The effect of dietary supplementation of b-carotene on lipid metabolism in streptozotocin-induced diabetic rats. Nutrition Research 24 1011-1021, 2004.

Interpretive Summary: Diabeties Mellitu is associated with increased risk for heart disease. We investigated the effectiveness of B-carotene in preventing the vacular complications of diabeties in rats. We found that B-carotene supplementation did not reduce blood glucose, but it did reduce total triglycerides. Additionally, B-carotene decrease the atherogenic index of these diabetic rats. Finally, B-carotene feeding tended to increase the excretion of cholesteroll and coprostanone, but not significantly. Our results suggest that B-carotene supplements may decrease the incidence of diabetic vascular complications, thus potentially decreasing the risk for heart disease.

Technical Abstract: Diabetic vascular complications such as atherosclerosis complicate the treatment of diabetes. We hypothesized that moderate supplementation with B-carotene might help prevent diabetic vascular complications through its impact on cholesterol metabolism. Forty Sprague-Dawley rats were fed AIN-76 control diet, or the same diet supplemented with 7.2 mg/kg diet B-carotene for three weeks, then diabetes was induced in half of the rats by streptozotocin. Diabetic and normal rats were fed the experimental diets for two more weeks. B-carotene did not reduce blood glucose in diabetic rats. Plasma triglycerides were increased by diabetes, but reduced by B-carotene. Total- and LDL-cholesterol were increased by diabetes. HDL-cholesterol did not differ between groups. B-carotene reduced cholesterol levels, but decreases were not significant. However, the atherogenic index of diabetic rats was higher than that of control rats, and B-carotene feeding decreased it. Fecal excretion of cholesterol and coprostanone were decreased by diabetes, and B-carotene tended to increase this excretion. Fecal excretion of bile acid showed similar tendencies, as did neutral steroids. These results suggest that dietary supplementation with B-carotene may reduce plasma triglycerides and other indices of diabetic risk, and thus may decrease the incidence of diabetic vascular complications through the normalization of lipid metabolism in diabetics.

Last Modified: 06/23/2017
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