Submitted to: Modern Nutrition in Health and Disease
Publication Type: Book / Chapter
Publication Acceptance Date: 12/20/2003
Publication Date: 8/15/2006
Citation: Burk, R.F., Levander, O.A. 2006. Selenium. In: Shils, M.E., Shike, M., Ross, A.C., Caballero, B., Cousins, R.J., editors. Modern Nutrition in Health and Disease. 10th edition. Philadelphia, PA: Lippincott Williams & Wilkins. p. 312-325.
Technical Abstract: The importance of selenium in human nutrition was documented in 1979 when Chinese scientists reported that selenium supplementation prevented the development of a heart muscle disease in children living in low-selenium areas. Also, New Zealand workers reported a clinical response to selenium in a selenium-depleted patient. Information about the role of selenium in human nutrition increased rapidly in the 1980's and a Recommended Dietary Allowance (RDA) for selenium was established n 1989 and was revised in 2000. Dietary recommendations from the World Health Organization (WHO) were issued in 1996. During the last 15 years, research has provided extensive new information on selenoproteins and the molecular biology of selenium.