Submitted to: Conference Research Workers Disease Meeting
Publication Type: Abstract only
Publication Acceptance Date: 11/10/2002
Publication Date: 11/10/2002
Citation: Elmowalid, G., Ransom, B.L., Braun, L.J., Young, A., Ridpath, J., Chase, C.C.L. Bovine viral diarrhea virus interferes with macrophage surface marker expression in vitro. Conference of Research Workers in Animal Diseases. 2002. Abstract No. 185. Interpretive Summary:
Technical Abstract: Surface markers molecules are important for macrophage cell functions. These markers may be receptors for microorganisms, co-receptors for signal transduction modulating cell response to various stimuli, complement regulatory proteins, or adhesion molecules crucial in cell-cell and cell matrix interactions. Bovine viral diarrhea virus (BVDV) is a major cattle pathogen that causes respiratory, reproductive and digestive tract diseases. Immunosuppression is known-documented phenomena associated with persistently or acutely affected cattle with BVDV. The effect of BVDV on macrophage surface markers (MHC I, MHC II, CD11b, CD11c or CD14) expression was investigated. Macrophages were i infected with a total of 8 different BVDV strains [non-cytopathic (NCP), cytopathic (CP); type 1 or 2] at different multiplicities of infection (m.o.i.) at different time intervals. Only NCP strains down-regulated MHC I. CP strains upregulated MHC I expression at the same time intervals and at the same m.o.i. MHC II expression was down-regulated in CP infected cells. CD11b and CD11c expression were not affected by BVDV infection. Infection with BVDV strains from persistently infected animals had a smaller effect on MHC II and CD14 expression than strains from acutely infected animals. Together, these results may explain the success of BVDV to establish persistent infection and to induce immunosuppression and secondary microbial infection.