|Burrin, Douglas - Doug|
Submitted to: Nutrition Conference Proceedings
Publication Type: Proceedings
Publication Acceptance Date: 5/14/2003
Publication Date: 5/14/2003
Citation: KANSAGRA, K., STOLL, B., ROGNERUD, C., OU, C., BURRIN, D.G. PARENTERAL NUTRITION DIMINISHES GUT BARRIER FUNCTION COMPARED TO ENTERALLY FED NEONATAL PIGLETS: A POSSIBLE ROLE FOR GLUCAGON-LIKE PEPTIDE-2. NUTRITION CONFERENCE PROCEEDINGS. 9th International Symposium on Digestive Physiology in Pigs, Banff, AB, Canada. 2003. v. II. p. 78-80. Interpretive Summary: Interpretive Summary not needed for this 115.
Technical Abstract: We tested whether intestinal permeability, bacterial translocation and inflammation are increased in TPN-fed (TPN) compared to enterally (ENT) fed piglets. After 6 d of treatment, piglets were given an oral gavage of permeability markers and urine collected. At 7 d, tissue was collected and bacterial cultures were obtained. Recovery of markers and myeloperoxidase (MPO) activity were higher in TPN versus ENT pigs, but translocation was not different. In another study, we tested whether intravenous glucagon-like peptide-2 plus TPN (GLP-2) can prevent the TPN-induced (TPN) increase in permeability. Recovery of lactulose, but not PEG 4000, was less in the GLP-2 than in the TPN group. Based upon these studies, we conclude that TPN increased intestinal permeability and mucosal inflammation. Moreover, treatment with GLP-2 partially blocked in the intestinal permeability in TPN-fed pigs.