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Title: THE ROLE OF GLUCOSE IN THE REGULATION OF PROTEIN SYNTHESIS IN THE NEONATE

Author
item O'CONNOR, PAMELA - BAYLOR COLLEGE MED
item KIMBALL, SCOT - PENN STATE COLLEGE MED
item ORELLANA, RENAN - BAYLOR COLLEGE MED
item NGUYEN, HANH - BAYLOR COLLEGE MED
item BUSH, JILL - BAYLOR COLLEGE MED
item SURYAWAN, AGUS - BAYLOR COLLEGE MED
item LIU, CHUN - BAYLOR COLLEGE MED
item Davis, Teresa

Submitted to: Federation of American Societies for Experimental Biology Conference
Publication Type: Abstract Only
Publication Acceptance Date: 3/1/2003
Publication Date: 3/1/2003
Citation: O'Connor, P.M., Kimball, S.R., Orellana, R.A., Nguyen, H.V., Bush, J.A., Suryawan, A., Liu, C.W., Davis, T.A. 2003. The role of glucose in the regulation of protein synthesis in the neonate [abstract]. Federation of American Societies for Experimental Biology Conference. Part II, 17(5):A810-A811.

Interpretive Summary: Not necessary for an Abstract

Technical Abstract: We have previously shown that insulin and amino acids (AA) regulate the feeding-induced stimulation of muscle and liver protein synthesis (PS) in neonates. To determine whether glucose (GLU) plays a role in the postprandial stimulation of PS in neonates, we performed pancreatic-substrate clamps in fasted, 7-d old pigs. Pigs (n-4/grp) were infused with somatostatin to block insulin secretion, GLU to achieve fasting or fed (80 or 220mg/dl) levels, INS to achieve fasting or fed (3 or 10uU/ml) levels, while AA were maintained at fasting or fed levels. Fractional PS and translation initiation factor activation were determined, GLU increased muscle PS by 34% when insulin and AA were at fasting levels, and by 109% when insulin and AA were at fed levels. Liver PS was increased by 25% only when fed levels of insulin and AA were infused with GLU. In the presence of fasting insulin and AA levels, GLU increased 4E-BP1 phosphorylation in muscle but not liver. There was no effect of GLU on eIF2B activity in both tissues. The results suggest that the postprandial rise in GLU contributes to the feeding-induced stimulation of muscle protein synthesis in the neonate.