Submitted to: Journal of Animal Science Supplement
Publication Type: Abstract Only
Publication Acceptance Date: 4/1/2003
Publication Date: 6/1/2003
Citation: Piva, A., Diaz, D.E., Casadei, G., Pagliuca, G., Galvano, F., Solfrizzo, M., Riley, R.T., Piva, G. 2003. PERFORMANCE AND BIOCHEMICAL PARAMETERS OF WEANLING PIGS CONSUMING CONTAMINATED DIETS WITH OR WITHOUT THE ADDITION OF ACTIVIATED CHARCOAL. Journal of Animal Science Supplement.Suppl. T53:116. Interpretive Summary: abstract only
Technical Abstract: Fumonisins are a group of mycotoxins that have been associated with toxicities in several species and that occur worldwide primarily in corn and corn based products. Fifty-six male weanling pigs (mean initial weight of 6.9 kg) were randomly assigned to pens and one of four treatments diets according to their initial weight. The treatment diets were: 1) Corn-soybean basal diet with < 2 ppm fumonisin (BD) 2) BD + Activated Carbon at 1% of the diet DM (AC), 3) BD + fumonisin (FUM) (30 ppm fumonisin), and 4) BD + AC + FUM (30 ppm fumonisin). A total of 4 replicates of 3 pigs/pen for treatments 3, and 4 and 4 piglets/pen for treatments 1, and 2 were utilized. Feed and water was offered ad libitum for the duration of the experiment (40 days). Pigs receiving fumonisin contaminated diets had a significantly (P<0.01) lower feed:gain as compared to DB animals (35.7%) without any improvement with the addition of activated charcoal. Liver enzymes GOT and GGT were significantly (P<0.01) higher for pigs consuming the FUM diet than for the BD pigs (304±38.2 vs. 73.12±38.1 and 123±26.7 vs. 35.87±26.9 UI/I respectively for GOT and GGT) again without any improvement due to the addition of activated charcoal. Similarly, serum cholesterol levels were significantly (P<0.01) higher for animals consuming fumonisin contaminated diets (3.21±0.18 vs. 2.03±0.19 mmol/l). Serum levels of total protein, bilirubin, glucose, urea, albumin, creatinine, calcium, phosphorous and magnesium were not significantly affected by dietary addition of fumonisin. Urinary sphinganine to sphingosine ratio, an effective biomarker for fumonisin toxicity in swine, was significantly (P<0.01) increased in pigs consuming fumonisin contaminated diets as compared to the BD diet (36.17±9.2 vs. 0.62±6.5). The consumption of diets contaminated with 30 ppm fumonisin significantly affected both performance and biochemical parameters in post weaned piglets. The addition of an activated charcoal added at 1% of the diet DM was not effective in protecting against the detrimental effects of fumonisin consumption.