Submitted to: Alcoholism: Clinical and Experimental
Publication Type: Proceedings
Publication Acceptance Date: 10/31/2002
Publication Date: 2/15/2003
Citation: BADGER, T.M., RONIS, M.J., SEITZ, H.K., ALBANO, E., INGELMAN-SUNDBERT, M., LEIBER, C.K. ALCOHOL METABOLISM: ROLE IN TOXICITY AND CARCINOGENESIS. ALCOHOLISM: CLINICAL AND EXPERIMENTAL. 2003. v. 27(2). p. 336-347.
Interpretive Summary: This article describes the proceedings of a symposium on effects of diet, alcohol and disease. The speakers were all world experts in this area and the conclusions were essentially that diet and metabolism play important roles in the health effects of alcohol, especially on prevention of diseases such as gastrointestinal cancers and liver diseases.
Technical Abstract: This article contains the proceedings of a symposium at the 2002 RSA Meeting in San Francisco, organized and co-chaired by Thomas M. Badger, Paul Shih-Jiun Yin, and Helmut Seitz. The presentations were (1) First-pass metabolism of ethanol: Basic and clinical aspects, by Charles Leiber; (2) Intracellular CYP2E1 transport, oxidative stress, cytokine release, and ALD, by Magnus Ingelman-Sundberg; (3) Pulsatile ethanol metabolism in intragastric infusion models: Potential role in toxic outcomes, by Thomas M. Badger and Martin J.J. Ronis: (4) Free radicals, adducts, and autoantibodies resulting from ethanol metabolism: Role in ethanol-associated toxicity, by Emanuele Albano; and (5) Gastrointentinal metabolism of ethanol and its possible role in carcinogenesis, by Helmut Seitz. Key Words: Alcohol, Metabolism, Liver, Gastrointentinal Tract, Cancer, Toxicity.