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Title: GENOME SEQUENCING OF THE UNITED STATES AVIAN PNEUMOVIRUS: DOES THE VIRUS CONTAIN THE SHORT HYDROPHOBIC GENE?

Author
item LWAMBA, H - UNIV OF MINNESOTA
item Alvarez, Rene
item Seal, Bruce
item NJENGA, M - UNIV OF MINNESOTA

Submitted to: American Society for Virology Meeting
Publication Type: Abstract Only
Publication Acceptance Date: 5/1/2003
Publication Date: 7/10/2003
Citation: Lwamba, H.M., Alvarez, R., Seal, B.S., Njenga, M.K. 2003. Genome sequencing of the united states avian pneumovirus: does the virus contain the short hydrophobic gene?. American Society for Virology Meeting.

Interpretive Summary:

Technical Abstract: Avian pneumovirus (APV) closely resembles human metapneumovirus (hMPV). APV causes an upper respiratory tract disease among turkeys. There are European subtype A, B and D viruses. The type C APV is a U.S. virus that causes disease outbreaks among north-central U.S. turkey flocks. The APV/C surface glycoprotein (G) gene was recently reported by our laboratories. However, the small hydrophobic protein (SH) gene was not detected in the viral genome. Although the G gene from the U.S. virus is longer than other reported pneumoviruses, there is a second potential transcriptional start site 715 nucleotides downstream of the full-length 1321 nucleotide G gene. Consequently, the SH gene may perhaps be present as a truncated G protein among U.S. APV isolates.