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ARS Home » Plains Area » Grand Forks, North Dakota » Grand Forks Human Nutrition Research Center » Healthy Body Weight Research » Research » Publications at this Location » Publication #150851
Title: EFFECTS OF DAILY SUBSTITUTION OF SOY PROTEIN FOR MEAT PROTEIN ON CALCIUM RETENTION AND BIOMARKERS OF BONE AND CARDIOVASCULAR HEALTH IN POSTMENOPAUSAL WOMEN

Author
item ROUGHEAD, ZAMZAM
item HUNT, JANET
item LYKKEN, GLENN - UNIV OF NORTH DAKOTA
item JOHNSON, LUANN - UNIV OF NORTH DAKOTA

Submitted to: Meeting Abstract
Publication Type: Abstract Only
Publication Acceptance Date: 6/26/2003
Publication Date: 9/21/2003
Citation: Roughead, Z.K., Hunt, J.R., Lykken, G.I., Johnson, L.K. 2003. Effects of daily substitution of soy protein for meat protein on calcium retention and biomarkers of bone and cardiovascular health in postmenopausal women [abstract]. Presented at the 5th International Symposium on the Role of Soy in Preventing and Treating Chronic Disease, Orlando, FL, September 21 - 25 , 2003.

Interpretive Summary:

Technical Abstract: The effects of substituting soy protein for meat protein on bone and cardiovascular health are not known. The primary aim of this controlled feeding study was to measure calcium (Ca) retention from a diet with meat (CONTROL) to a diet in which 25 g/day of soy protein (SOY; 3.72 mg isoflavones/g protein) was substituted for an equivalent amount of meat protein. The secondary objective was to measure the effects of these diets on indicators of cardiovascular health. Healthy postmenopausal women (n=13, age:52-69 y; BMI: 26.0 ± 5.0) consumed the diets (15% protein, 30% fat; 653 and 740 mg Ca/2200 kcal in the CONTROL and SOY diets, respectively), for 8 wk each, in a randomized crossover design. After 4 wk of equilibration, the 2-d cycle menu was extrinsically labeled with Ca-47 isotope and its retention was monitored for 28 d by whole body scintillation counting. The fractional absorption and final retention of the Ca tracer (mean ± SD) were not different between the diets (absorption: 26.1 ± 7.0, and 27.0 ± 7.0; day 28 retention: 14.1 ± 3.2 and 14.0 ± 4.1, % of dose, for CONTROL and SOY diets, respectively; P>0.05). Diet also did not affect blood and urinary biomarkers of bone metabolism, serum lipids (cholesterol, HDL, LDL, VLDL, triglycerides) and serum homocysteine. In conclusion, a daily substitution of 25 g of a soy protein isolate for meat protein for 8 wk did not affect the efficiency of Ca retention or indicators of bone and cardiovascular status in healthy postmenopausal women.