Submitted to: Biologicals
Publication Type: Book / Chapter
Publication Acceptance Date: 6/1/2002
Publication Date: 6/1/2003
Citation: Fulton, R.W., Ridpath, J.F., Confer, A.W., Saliki, J.T., Burge, L.J., Payton, M.E. Bovine viral diarrhoea virus antigenic diversity: impact on disease and vaccination programmes. Biologicals. 2003. v. 31. p. 89-95. Interpretive Summary:
Technical Abstract: Bovine viral diarrhea virus (BVDV) infections in cattle are associated with a variety or "diverse" clinical forms. These include digestive tract disease, respiratory disease, fetal diseases (varied, dependent on fetal age), systemic disease such as mucosal disease, immunosuppression, hemorrhagic disease, and inapparent infections. The BVDV isolates themselves are "diverse" such as genotype differences based on nucleotide sequences, antigenic variability and biotype definitions (presence or absence of cytopathology) in cell culture. Two predominant genotypes are present in the U.S., BVDV 1 and BVDV2. There are subtypes of BVDV1, BVDV1a, and BVDV1b. BVDV isolates from cattle derived from diagnostic laboratory submissions indicate that BVDV1b subtype were as prevalent if not more prevalent than BVDV1a among BVDV1 isolates. There was an almost equal distribution of BVDV1b and BVDV1a isolates from cattle with history of respiratory disease, and more isolates, 6 versus 2, of BVDV1b than for BVDV1a in necropsy cases of pneumonias. There were significant antibody titer differences in serums from calves receiving modified-live virus vaccines containing BVDV1a as the BVDV1b antibody titers were significantly lower than to BVDV1a. A survey of the U.S. licensed and marketed BVDV vaccines indicate that only one vaccine contains BVDV1b with the others containing BVDV1a or undesignated BVDV1.