Submitted to: Journal of Natural Products
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: 3/24/2003
Publication Date: 8/22/2003
Citation: Angawi, R.F., Swenson, D.C., Gloer, J.B., Wicklow, D.T. 2003. Lowdenic acid: a new antifungal polyketide-derived metabolite from a new fungicolous verticillium sp. Journal of Natural Products. 66(9):1259-1262. Interpretive Summary: Fungi that parasitize and kill other fungi offer a potential source of novel antifungal agents useful to agriculture and medicine. A previously undescribed species of Verticillium NRRL 29280, encountered as a colonist and potential parasite of the wood decay fungus Poria, collected at Lowden State Park in Illinois, was examined for its ability to produce antifungal agents and other bioactive metabolites. Lowdenic acid is reported as a new antifungal metabolite which displayed potent activity against Aspergillus flavus.
Technical Abstract: Lowdenic acid (1), a new antifungal metabolite with an unusual structure and a mixed biogenetic origin, has been obtained from non-sporulating cultures of a previously undescribed Verticillium sp. (MYC-406 = NRRL 29280) that was isolated as a colonist of polypore basidiomata. The gross structure of 1 was proposed by analysis of NMR data, and confirmed by X-ray diffraction analysis, which enabled assignment of relative stereochemistry. Compound 1 occurs as an equilibrium E/Z mixture. The known antifungal metabolite canescin A (2) was also isolated.