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Title: NEW CELL-CELL ADHESION INHIBITORS FROM STREPTOMYCES SP. UMA-044

Author
item ZHANG, QINGLIN - UNIVERSITY OF MISSISSIPPI
item Schrader, Kevin
item ELSOHLY, HALA - UNIVERSITY OF MISSISSIPPI
item TAKAMATSU, SATOSHI - UNIVERSITY OF MISSISSIPPI

Submitted to: Journal of Antibiotics
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: 7/8/2003
Publication Date: 8/11/2003
Citation: ZHANG, Q., SCHRADER, K., ELSOHLY, H.N., TAKAMATSU, S. NEW CELL-CELL ADHESION INHIBITORS FROM STREPTOMYCES SP. UMA-044. JOURNAL OF ANTIBIOTICS. 2003. V. 56(8). P. 673-681.

Interpretive Summary: Two new compounds were discovered from a type of bacteria isolated from catfish pond sediments that help prevent processes that cause inflammation in humans. These new compounds may be useful as novel therapeutic drugs for inflammatory diseases such as rheumatoid arthritis.

Technical Abstract: Three compounds, NP25301, NP25302 and bohemamine, inhibitors of cell adhesion based on LFA-1/ICAM-1, were isolated from the cultured broth of the strain Streptomyces sp. UMA-044. New compounds NP25301 and NP25302 were identified as 2-(3'-hydroxybenzamide) acrylic acid methylester and deoxybohemamine, respectively, based on streptoscopic analyses. Compounds NP25301, NP25302 and bohemamine inhibited adhesion of HL-60 cells to CHO-ICAM-1 cells at IC50 values of 29.5 ug/mL, 24.3 ug/mL, and 27.2 ug/mL, respectively.