Submitted to: Nutrition Reviews
Publication Type: Review Article
Publication Acceptance Date: 3/1/2003
Publication Date: 8/1/2003
Citation: Finley, J.W. 2003. The antioxidant responsive element (ARE) may explain the protective effects of cruciferous vegetables on cancer. Nutrition Reviews. 61 (7):250-254. Interpretive Summary:
Technical Abstract: Research supports the hypothesis that diet greatly impacts risk of cancer. Many studies have found that increased fruit and vegetable intake decreases the risk of cancer. Cruciferous vegetables such as broccoli and cauliflower seem to be especially protective against cancer. Most studies show that phytochemicals in crucifers upregulate many detoxification enzyme systems in the animal that consumes them. Recent reports of the molecular events involved in the activation of a gene promoter termed the Antioxidant Responsive Element (ARE) have begun to provide clues as to how a single substance may induce a battery of many genes.