Page Banner

United States Department of Agriculture

Agricultural Research Service

Title: A MICROCANTALEVER-BASED PATHOGEN DETECTOR)

Author
item Weeks, B.
item Camarero, J.
item Noy, A.
item Miller, A.e.
item Stanker, Larry
item De yoreo, J.j.

Submitted to: Symposium Proceedings of Nanotechnology Conference 2003
Publication Type: Abstract only
Publication Acceptance Date: 2/23/2003
Publication Date: 2/23/2003
Citation: Weeks, B.L., Camarero, J., Noy, A., Miller, A., Stanker, L.H., De Yoreo, J. 2003. A microcantalever-based pathogen detector. Symposium Proceedings of Nanotechnology Conference 2003.

Interpretive Summary: The ability to detect small amounts of materials, especially bacterial organisms, is important for medical diagnostics and national security issues. Engineered micro-mechanical systems provide one approach for constructing multifunctional, highly sensitive, real-time, immunospecific biological detectors. We present qualitative detection of specific Salmonella strains using a functionalized silicon nitride microcantilever. Detection is achieved due to a change in the surface stress on the cantilever surface in-situ upon binding of a small number of becteria. Scanning electron micrographs indicate that less than 25 adsorbed bacteria are required for detection.

Technical Abstract: The ability to detect small amounts of materials, especially bacterial organisms, is important for medical diagnostics and national security issues. Engineered micro-mechanical systems provide one approach for constructing multifunctional, highly sensitive, real-time, immunospecific biological detectors. We present qualitative detection of specific Salmonella strains using a functionalized silicon nitride microcantilever. Detection is achieved due to a change in the surface stress on the cantilever surface in-situ upon binding of a small number of becteria. Scanning electron micrographs indicate that less than 25 adsorbed bacteria are required for detection.

Last Modified: 8/24/2016
Footer Content Back to Top of Page