Submitted to: Tetrahedron Letters
Publication Type: Peer reviewed journal
Publication Acceptance Date: 12/4/2002
Publication Date: 6/3/2003
Citation: Kasanah, N., Rao, K.V., Yousaf, M., Wedge, D.E., Hamann, M.T. 2003. The biocatalytic conversion of 8-hydroxymanzamine A to manzamine A using Fusarium solani. Tetrahedron Letters. 44(6):1291-1293. Interpretive Summary: This paper describes two biological test systems in which the plant pathogen Fusarium solani and the microorganism Streptomycetes seokies convert 8-hydroxymanzamine to the more active antimalarial compound manzamine A. These organisms can perform biotransformation and production of important medicinal compounds that are very difficult to achieve through synthetic approaches.
Technical Abstract: The selective dehydroxylation of 8-hydroxymanzamine A (1) to form manzamine A (2) can be completed by fermentation with Fusarium solani or Streptomyces seokies. This unique biocatalytic conversion is important due to the fact that the manzamine A has significantly more desirable biological activity when assayed in a murine model against malaria.