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Title: PROTECTIVE EFFICACY OF AN INACTIVATED AVIAN INFLUENZA VACCINE AGAINST CHALLENGE WITH A 2002 H7N2 AVIAN INFLUENZA ISOLATE

Author
item Tumpey, Terrence
item Swayne, David

Submitted to: Western Poultry Disease Conference
Publication Type: Abstract Only
Publication Acceptance Date: 1/1/2003
Publication Date: 3/1/2003
Citation: Tumpey, T., Swayne, D.E. 2003. Protective Efficacy of an Inactivated Avian Influenza Vaccine Against Challenge With a 2002 H7N2 Avian Influenza Isolate. Western Poultry Disease Conference Proceedings, CD-Rom, 2003.

Interpretive Summary:

Technical Abstract: The outbreak of H7N2 low pathogenicity avian influenza (LPAI) in Virginia this past year raised questions about the potential of available vaccines to provide protection in poultry. In vaccine trials, neither sham-vaccinated nor H7N2-vaccinated turkeys developed clinical signs or death following challenge with A/turkey/Virginia/158512/02 (H7N2) LPAI virus. The inactivated vaccine groups (1x and 2x vaccinated) had a significant reduction in titers of challenge virus shed from the oropharynx when compared to sham-vaccinated groups for days 1-7 after challenge. These studies suggest that a currently available commercial vaccine can provide protection to a recent H7N2 avian influenza isolate.