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Title: EFFECTS OF VIRULENT AND VACCINE STRAINS OF MAREK'S DISEASE VIRUS ON SUBGROUP J AVIAN LEUKOSIS VIRUS INFECTION IN MEAT-TYPE CHICKENS

Author
item YONDEM, BEDRIYE - MSU PATHOBIOLOGY
item REED, WILLIE - MSU PATHOBIOLOGY
item Fadly, Aly

Submitted to: Workshop on Molecular Pathogenesis of Marek's Disease and Avian Immunology
Publication Type: Abstract Only
Publication Acceptance Date: 10/6/2002
Publication Date: 12/31/2002
Citation: YONDEM, B., REED, W., FADLY, A. EFFECTS OF VIRULENT AND VACCINE STRAINS OF MAREK'S DISEASE VIRUS ON SUBGROUP J AVIAN LEUKOSIS VIRUS INFECTION IN MEAT-TYPE CHICKENS. WORKSHOP ON MOLECULAR PATHOGENESIS OF MAREK'S DISEASE AND AVIAN IMMUNOLOGY. 2002. ABSTRACT P. 81.

Interpretive Summary:

Technical Abstract: The objective of this study was to determine the influence of virulent and vaccine strains of Marek's disease virus (MDV) on subgroup J avian leukosis virus (ALV-J) -induced viremia and cloacal shedding in meat-type chickens. Chickens from two lines were infected with ALV-J at hatch; chickens were also inoculated with various strains of MDV vaccines at hatch and challenged with very virulent plus (vv+) MDV at two weeks of age. The incidence of ALV-J viremia and cloacal shedding in chickens vaccinated with bivalent MDV vaccine was lower than that in chickens inoculated with serotype 1 MDV vaccine (Rispens) or vv+MDV (strain 648A). In a second experiment, chickens infected with ALV-J and vaccinated with serotype1 MDV vaccine at hatch had the highest incidence of viremia and cloacal shedding. Data from this study suggest that bivalent MDV vaccines containing serotype 2 and 3 MDV, namely turkey herpesvirus and SB-1 (HVT+SB-1) reduced ALV-J viremia and cloacal shedding in one of the two chicken lines used.