Submitted to: Proceedings of the National Academy of Sciences
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: 7/31/2002
Publication Date: 7/31/2002
Citation: Tepperman, J.M., Zhu, T., Chang, H.S., Wang, X., Quail, P.H. 2002. Multiple transcription-factor genes are early targets of phytochrome a signaling. Proceedings of the National Academy of Sciences, 7/31/01 V. 98(16):9437-9442. Interpretive Summary: We have identified a master set of transcriptional regulators that are responsible for orchestrating the expression of multiple downstream target genes in response to light signals mediated by phytochrome A (phyA).
Technical Abstract: The phytochrome family of sensory photoreceptors directs adaptational changes in gene expression in response to environmental light signals. Using oligonucleotide microarrays to measure expression profiles in wild-type and phytochrome A (phyA) null-mutant Arabidopsis seedlings, we have shown that 10% of the genes represented on the array are regulated by phyA in response to a continuous far-red light signal. Strikingly, 44% of the genes responding to the signal within 1 h are predicted to encode multiple classes of transcriptional regulators. Together with previous data, this observation suggests that phyA may regulate seedling photomorphogenesis by direct targeting of light signals to the promoters of genes encoding a master set of diverse transcriptional regulators, responsible in turn for orchestrating the expression of multiple downstream target genes in various branches of a phyA-regulated transcriptional network.