Submitted to: Book Chapter
Publication Type: Book / Chapter
Publication Acceptance Date: 10/17/2002
Publication Date: 6/1/2003
Citation: CARLSON, S.A., WU, M.T., FRANA, T.S. MULTIPLE ANTIBIOTIC RESISTANCE AND VIRULENCE OF SALMONELLA ENTERICA SEROTYPE TYPHIMURIUM PHAGETYPE DT104. ISAACSON, R.E., TORRENCE, M.E., EDITORS. IOWA STATE UNIVERSITY PRESS, AMES, IA. CURRENT TOPICS IN FOOD SAFETY IN ANIMAL AGRICULTURE. 2003. P. 123-129.
Technical Abstract: Salmonella infections are an important health concern in both industrialized and developing countries. Treatment of this microorganism is compromised by its ability to acquire resistance to multiple antibiotics. Monitoring of Salmonella isolates in the United States and abroad has shown that increasing proportions are resistant to several antimicrobial agents. Of particular concern is a unique strain of Salmonella enterica serotype Typhimurium, characterized as definitive type 104 (DT104), that is commonly resistant to five antibiotics (ampicillin, chloramphenicol, streptomycin, sulfonamides, and tetracycline; ACSSuT antibiogram). First reported in the United Kingdom in 1984, DT104 is now the second most prevalent Salmonella isolated from humans in England and Wales. Salmonella infections caused by multiresistant DT104 have also been reported in cattle, swine, marine wildlife, cats, and a variety of other species. Additionally, DT104 and related multiresistant Salmonella were recently detected in approximately 50% of retail ground meats. The virulence of DT104 is also of concern since, relative to an infection with a non-DT104 Salmonella, an infection with DT104 is more likely to lead to hospitalization for a human or death for a calf. These phenomena suggest that DT104 may be more virulent due to alterations in inherent pathogenic characteristics, acquisition of new virulence characteristics or treatment failures resulting from the use of inappropriate antibiotics. Therefore, DT104 represents a major obstacle for preserving food safety.