Submitted to: OSF Health Summit
Publication Type: Abstract Only
Publication Acceptance Date: 8/15/2002
Publication Date: 10/11/2012
Citation: Finkenstadt, V.L., Hitt, H., Willett, J.L. 2012. EXPANDED STARCH AS A FLOATING DOSAGE MATRIX FOR THE CONTROLLED RELEASE OF MODEL DRUG COMPOUNDS. OSF Health Summit. xx. Interpretive Summary:
Technical Abstract: Starch-based materials were tested using model drug compounds to determine the feasibility of using starch as an oral floating dosage matrix. Oral controlled release systems require increased bio-availability, predictable release rates, and site-specific delivery. Starch and model drugs were compounded and blended, then "puffed" on a single screw extruder to form an expanded, low density delivery matrix. Model drug compounds were chosen for specific functionality. Materials were characterized for pore size, porosity, controlled release in an aqueous environment, and mechanical properties including buoyancy and overall strength. Extrusion conditions were found to play a role in the expansion of starch and mechanical properties for the production of a floating dosage matrix. Expanded starch showed an increase in release of model drug compounds compared to unexpanded starch.